ERG and Smad3 Proteins Collaborate to Activate TGF-Beta Mediated Signaling Pathway in ERG-Positive Prostate Cancer Cells
African-American men have twice the risk of developing prostate cancer as Caucasian men. ERG gene (discovered by us) was found to be involved in a majority of human Prostate cancers (50-80%). In this study, we demonstrate that ERG oncoprotein physically interacts with Smad3 protein and stabilizes phospho-Smad3 protein and thereby enhance TGF-b/Smad3 signaling pathway in prostate cells. Thus, ERG oncoprotein plays an important role in prostate tumorigenesis by using a novel mechanism to activate TGF-beta/Smad3 signaling pathway. These results will have great implications in the diagnosis and treatment of ERG-positive Prostate cancers.
Jinbo Fang, Huali Xu, Chunshu Yang, Sharif Morsalin, Shubhalaxmi Kayarthodi, Kunchala Rungsrisuriyachai, Ujwala Gunnal, Brittany Mckenzie, Veena N. Rao, and E. Shyam P. Reddy, Journal of Pharmaceutical Sciences and Pharmacology, Volume 1, Number 3, September 2014, pp. 175-181(7)
Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in ETS Related Gene-Positive Prostate Cancers
(Journal of Pharmaceutical Sciences and Pharmacology, 1, 82-85, 2014)
Dr Reddy, Dr Rao and his colleagues (Jinbo Fang, Huali Xu, Chunshu Yang, Shubha Kayarthodi, Roland Matthews,Veena N. Rao, and E. Shyam P. Reddy) discovered novel mechanism by which ERG oncoprotein regulates TGF-beta signaling pathway in ERG-positive prostate cancer. It appears that ERG oncoprotein plays an important role in prostate tumorigenesis by activating TGF-β signaling pathway.Thus, these results will have great implications in the diagnosis and treatment of ERG-positive Prostate cancers.
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