Functionotherapeutics: Gene Discovery and Function based Therapeutic Strategies

   
 Genes/Gene functions discovered by us:

1. ERG-1                      3476934    PNAS, Oncogene              

2. ERG-2                      3299708    Science, Oncogene

3. ERG-3                      8290279    Oncogene    

4. ELK-1                       2539641   Science, Nature, Cancer Res

5. ETS-2                       1741383    PNAS     

6. ETS-1a                     3060801   Oncogene

7. Human Fli-1             1394211   Cancer Res, Oncogene 

8. Fli-1b                        9764825   Oncogene                 

9. EWSb                       8084618   Oncogene

10. EWS-Fli-1               7503813   Cancer Res, Oncogene

11. EWS-ERG               8084618   Oncogene  

12. TLS/FUS-ERG        7970732   Oncogene

13.TLS/FUS                  7970732   Oncogene

14. EWS-ATF-1             8552387   Oncogene

15. BRCA2a                  10023017 Oncogene, Nature

16. PTENb                    Unpublished

17. BRCA1a                  9538156   Oncology Rep.

18. BRCA1b                  9538156   Oncology Rep.

19. Delta ELK-1            8417810   Cancer Res.

20.  H2-K K Gene           3840763             Gene

21. mi-PEP-200a          In PRESS           

22. mi-PEP-200b          In PRESS

23. Seminalplasmin     Nature (back to back papers, Ph.D. Thesis)

                                                                                 

Grant awards

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• Swebelius Cancer Research Award of Yale University (Awarded twice) (PI)

• NIH RO1 – “Functional dissection of Human ets‑1 gene” NIH 1RO1‑CA 57157 (PI)

• ACS - "Functional Dissection of Human Fli-1 gene" ACS #VM 69
  

• NIH RO1– “Functional role of Fli‑1 in neoplasia” NIH 1 RO1‑CA5864 (PI)

• NIH PO1 – “Structural and Function of c‑ets‑1 Proto‑oncogene” -NIH 1PO1‑CA51083 (PI)

• NIH 2 RO1‑CA58642 – “Functional role of Fli-1 in neoplasia” (PI)

• DOD-“Tumor Suppressors and Breast Cancer” DAMD-17-99-1-9060 (PI) 

• NIH RO1 – “Role of EWS-ATF-1 in neoplasia”- NIH 1RO1-CA78708 (PI)

• Georgia Cancer Coalition Distinguished Cancer Scholar (1.2 million dollars  from the Governor of Georgia) (PI)
  

• NIH-P60 Function–Based Therapeutic Approaches to Human Cancers

• NIH  U56 CA92078 (PI)
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• NIH  U54 (PI)
  
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• NIH U54 2U54CA118948 (PI)
  
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• NIH U54 (Pilot)-Co PI
  
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• UAB Pancreatic Spore, Pilot (PI)
  
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• DOD IDEA AWARD- (PI) Function based therapeutic strategies to human prostate cancer
  

• UAB Breast Spore-Pilot (PI)
  
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• DOD- ERG and prostate cancer (PI) W81XWH-09-1-0236
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• DOD-BRCA2 and Breast cancer (PI) W81XWH-10-1-0418

• NIH-ARRA award CA118638-05S1 (PI)
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• NIH S21MD000101
  

We are grateful to NIH, ACS, Georgia Governer, DOD Army for providing grants to support our Cancer research



Dr Reddy is thankful to all individuals (Postdoctoral fellows, Graduate students, junior faculty and collaborators)  who worked passionately and contributed to the discovery of these genes and their function.

Our passion is to find a cure to cancer. Nothing great can be achieved without a passion.