to
PROSTATE CANCER, EWING SARCOMA, BREAST CANCER, LUNG CANCER, OVARIAN CANCER, PANCREATIC CANCER
Dr E. Shyam P. Reddy,
Functionotherapeutics,
Professor and Director, Cancer Biology Program, Dept of OB/GYN, Morehouse School of Medicine, 720 Westview Drive
Atlanta, GA 30310
ph: 404-756-5230
fax: 678-623-5999
ereddy
Recently Dr Shyam Reddy and his colleagues have made novel discoveries in Cancer Genomics and Cancer Therapy. Please watch for these two new findings soon (In press).The discovery in Cancer Genomics may revolutionize future biology.
Dr Reddy’s group has decoded Non-coding DNA (JUNK DNA) and its non-coding RNA and discovered novel category Pri-Micro RNA-Encoded Proteins/ Peptides in mammalian cells. Pri-Micro RNA-200a and Pri-Micro RNA-200b encode NOVEL Tumor Suppressors (mi-PEP-200a and mi-PEP-200b) which inhibit migration of Prostate and Breast cancer cells. This finding suggests that thousands of new functional proteins/peptides are encoded by non-coding RNAs in the mammalian genome. This will revolutionize the future biology, diagnosis and precision therapy.
Fang, Jinbo, Morsalin, Sharif, Rao, Veena N., Reddy, E. Shyam P. Decoding of Non-Coding DNA and Non-Coding RNA: Pri-Micro RNA-Encoded Novel Peptides Regulate Migration of Cancer Cells. J. Pharm. Sci. Pharmacol. 2017;3:23–27. [Google Scholar].
Reviewed :
Wang J, Zhu S, Meng N, He Y, Lu R, Yan GR. ncRNA-Encoded Peptides or Proteins and Cancer. Mol Ther. 2019 Oct 2;27(10):1718-1725. doi: 10.1016/j.ymthe.2019.09.001. Epub 2019 Sep 6. PMID: 31526596; PMCID: PMC6822234.
Zhu S, Wang J, He Y, Meng N, Yan GR. Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers. Front Pharmacol. 2018 Nov 13;9:1295. doi: 10.3389/fphar.2018.01295. PMID: 30483132; PMCID: PMC6243196.
Journal of Pharmaceutical Sciences and Pharmacology (aspbs.com)
Decoding of Non-Coding DNA and Non-Coding RNA: Pri-Micro RNA-Enco...: Ingenta Connect (doi.org)
ERG and Human Fli-1 Transcriptional Factors (discovered by us) Play a role in the Precision Treatment of Pulmonary Arterial Hypertension and Pulmonary Fibrosis.
(Titilope Olanipekun, Nicolas Bakinde, Kelsey Paul-Stubbs, Ajose Taiwo, Sharif Morsalin, Samir Yezdani, Veena N Rao and E . Shyam P. Reddy, Journal of Cancer epidemiology & Tratment, 3,1-4, 2019).
Dr Reddy's group recently discovered a Novel gene (MRI-1, Master Regulator of Imprinting) that is responsible for 40-70% of Breast and Ovarian cancers. This gene is also involved in several Womens Health issues. These results will greatly accelerate diagnosis and precision therapy of the Women's cancers and diseases mentioned above. (2021 in press)
Please click the link below for more News:
https://www.ajc.com/lifestyles/health/movember-effort-fight-cancer/mDH8hGW6Jfa9wtY2cl0CfJ/
Functionotherapeutics, Cancer Biology Program, Morehouse School of Medicine Receives 2020 Best of Atlanta Award
Atlanta Award Program Honors the Achievement
ATLANTA January 9, 2020 -- Functionotherapeutics, Cancer Biology Program, Morehouse School of Medicine has been selected for the 2020 Best of Atlanta Award in the Colleges & Universities category by the Atlanta Award Program.
Novel PRECISION THERAPY for Prostate Cancer was discovered by Morehouse School of Medicine Scientists at Cancer Biology Program, Dept of OB/GYN, Georgia Cancer Center for excellence, Grady Hospital, Atlanta
In the United States of America, prostate cancer is the second most common age-related cancer among men. African-American men have the highest incidence of, and mortality rate from this disease and they have twice the risk of developing prostate cancer as Caucasian men. ERG gene (discovered by us) was found to be involved in a majority of human Prostate cancers (50-80%). Another ERG/ETS related gene, ETV1 is believed to be responsible for 10% of prostate cancer.
In order to understand the molecular mechanism by which ETV1 cancer protein causes prostate cancer, Dr Reddy and his Ph.D. student Sharif Morsalin in collaboration with other scientific colleagues Drs Chunshu Yang, Jinbo Fang, Sampreet Reddy, Shubhalaxmi Kayarthodi, Ed Childs, Roland Matthews, Veena N Rao ( from Cancer Biology Program, Dept of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Memorial Hospital, Atlanta ) discovered that ETV1 cancer protein induces certain enzymes ( kinases) in cancer cells which deregulate the critical protein beta-catenin by protein modification. They have also identified therapeutic agent (commercially available) that interferes with this process. In addition, they have demonstrated that this therapeutic agent targets these cancer cells effectively. These therapeutic agents will have a profound impact on prevention and treatment of prostate cancer which may help to reduce health disparity seen in minority prostate cancer patients. They also believe that such targeted mechanistic studies will help patients not to undergo unnecessary and more dramatic chemo- therapy treatment
Molecular Mechanism of β-Catenin Signaling Pathway Inactivation in ETV1-Positive Prostate Cancers. Sharif Morsalin, Chunshu Yang, Jinbo Fang, Sampreet Reddy, Shubhalaxmi Kayarthodi, Ed Childs, Roland Matthews, Veena N Rao and E. Shyam P. Reddy. Journal of Pharmaceutical Sciences and Pharmacology, Volume 1, Number 2, , pp. 87-100(14)
National Prostate Cancer Awareness Month (September)
ERG and Smad3 Proteins Collaborate to Activate TGF-Beta Mediated Signaling Pathway in ERG-Positive Prostate Cancer Cells
African-American men have twice the risk of developing prostate cancer as Caucasian men. ERG gene (discovered by us) was found to be involved in a majority of human Prostate cancers (50-80%). In this study, we demonstrate that ERG oncoprotein physically interacts with Smad3 protein and stabilizes phospho-Smad3 protein and thereby enhance TGF-b/Smad3 signaling pathway in prostate cells. Thus, ERG oncoprotein plays an important role in prostate tumorigenesis by using a novel mechanism to activate TGF-beta/Smad3 signaling pathway. These results will have great implications in the diagnosis and treatment of ERG-positive Prostate cancers.
Jinbo Fang, Huali Xu, Chunshu Yang, Sharif Morsalin, Shubhalaxmi Kayarthodi, Kunchala Rungsrisuriyachai, Ujwala Gunnal, Brittany Mckenzie, Veena N. Rao, and E. Shyam P. Reddy, Journal of Pharmaceutical Sciences and Pharmacology, 1, 175-181.
(Journal of Pharmaceutical Sciences and Pharmacology, 1, 82-85)
Childhood Cancer Awareness Month (September)
Anti-Epileptic Drug Targets Ewing Sarcoma
Our results (Ph.D. student Shubhalaksmi K. et al., and Reddy) demonstrate that anti-epileptic drug relieves the inhibitory effect of oncoproteins involved in Ewing family of tumors and targets these cancer cells. (Repurposing of existing drugs towards therapy of EWING SARCOMA)
Therapeutic regulation of transcriptional repressor properties of EWS-ERG/EWS-Fli-1 with an anti-Epileptic drug with a promising new potential might have a profound impact on prevention, management and treatment of Ewing Sarcoma. Therapeutic use of FDA approved anti-Epileptic drug in minority patients may help reduce the health disparity seen in Ewing family of tumors. [Shubhalaxmi Kayarthodi, Yasuo Fujimura, Jinbo Fang, Sharif Morsalin, Veena N. Rao, and E. Shyam P. Reddy (Journal of Pharmaceutical Sciences and Pharmacology, 1, 87-100].
Shubhalakshmi Kayarthodi was also awarded The Anthony Shuker Scientific Poster Award for her poster " Molecular mechanism of inactivation of nuclear receptor function in ERG-positive Ewing Sarcoma" (Dr Reddy, Mentor) (GEORGIA Life Sciences Summit). She also received Outstanding Ph.D. Graduate student award in the Biomedical sciences (Ph.D), Morehouse School of Medicine.
AWARDS:
Dr Reddy received GCC Distinguished Cancer Scholar award (1.25 million dollars) from the Governor of Georgia
Dr Reddy received Outstanding Advisor Ph. D. class, Morehouse School of Medicine.
The prestigious Super Achievers of India Award and Gold Medal
Center for Prostate Disease Research Distinguished Visiting Professor Award
[Please see below]
Dr Shyam Reddy discovered and cloned several cancer genes/oncogenes (close to 20 genes) and studied their functions. The most notable genes discovered by Dr Reddy include ERG-1, ERG-2, ERG-3 and human FLI-1genes(published in prestigious journals Science, PNAS and Oncogene). Dr Reddy named the gene as ERG ( ETS Related Gene). ERG is a transcriptional factor and a MASTER gene of Blood cells. It is also a stem cell factor and also involved in 50-80% of Prostate cancers, Ewing Sarcoma and also leukemias (AML).
Other notable ETS genes discovered and studied by Dr Reddy include human Fli-1 (involved in 80% of Ewing family of tumors, Leukemias and Prostate cancer), EWS-Fli-1 (involved in 80% of Ewing Sarcoma, Pediatric cancer), EWS-erg (involved in Ewing Sarcoma), TLS-erg (involved in Acute Myeloid Leukemia), EWS (involved in multiple cancers), TLS/FUS (involved in multiple cancers), ELK-1 (Drs Reddy and Rao named this gene as ETS Like Gene, published in Science journal), BRCA1a, BRCA1b, BRCA2a (involved in breast, ovarian and prostate cancers) and EWS-ATF-1 (malignant Melanoma of Soft Parts/Clear cell sarcoma)
Gene Discovery / Road Map to Therapy, About Us, Our Achievements
Gene Discovery / Road Map to Therapy, Our Achievements
Call Us
Gene Discovery/Road map to Therapy
Our passion is to find a cure to cancer. Nothing great can be achieved without a passion.
Genes/Gene functions discovered by us:
1. ERG-1 3476934 PNAS, Oncogene
2. ERG-2 3299708 Science, Oncogene
3. ERG-3 8290279 Oncogene
4. ELK-1 2539641 Science, Nature, Cancer Res
5. ETS-2 1741383 PNAS
6. ETS-1a 3060801 Oncogene
7. Human Fli-1 1394211 Cancer Res, Oncogene
8. Fli-1b 9764825 Oncogene
9. EWSb 8084618 Oncogene
10. EWS-Fli-1 7503813 Cancer Res, Oncogene
11. EWS-ERG 8084618 Oncogene
12. TLS/FUS-ERG 7970732 Oncogene
13.TLS/FUS 7970732 Oncogene
14. EWS-ATF-1 8552387 Oncogene
15. BRCA2a 10023017 Oncogene, Nature
16. PTENb Unpublished
17. BRCA1a 9538156 Oncology Rep.
18. BRCA1b 9538156 Oncology Rep.
19. Delta ELK-1 8417810 Cancer Res.
20. H2-K K Gene 3840763 Gene
21. mi-PEP-200a In PRESS
22. mi-PEP-200b In PRESS
23. Seminalplasmin Nature (back to back papers, Ph.D. Thesis)
Grant awards
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We are grateful to NIH, ACS, Georgia Governer, DOD Army for providing grants to support our Cancer research
Dr Reddy was awarded the globally reputed " LIFETIME ACHIEVEMENT AWARD" for his contribution to Cancer Research by IIFS at New Delhi.
MAHATMA GANDHI PRAVASI GOLD MEDAL
Dr Shyam Reddy was awarded the prestigious MAHATMA GANDHI PRAVASI GOLD MEDAL during IIFS function of Global Achievers Conclave at the HOUSE OF LORDS, Parliament, London, UK.
Indians are making considerable contributions and are dominating all over the world in their field of profession and are creating wonders with their Midas Touch. They have earned laurels and have achieved excellence.
The most eminent achievers, who have made a place for themselves in their profession and are keeping flag of India high, will be honored with “MAHATMA GANDHI PRAVASI GOLD MEDAL” during the conference as Mahatma Gandhi was the First Pravasi who left an impeccable mark in the history of the world.
http://www.gofundme.com/6x6kn4
Dr Shyam Reddy was awarded "INTERNATIONAL GOLD STAR AWARD" by His Excellency Korn Dabbransi, former Deputy Prime Minister, Thailand for individual excellent performance and contribution for the progress of the Nation and worldwide in the field of Science and Medicine.
LINK:
Best Personalities of India Award and Gold Medal:
Dr Shyam Reddy was awarded the prestigious Best Personalities of India Award and Gold Medal (certificate of Excellence) (certificate of Felicitation) during a conference on Economic growth and National Unity by Dr.G.V.G.Krishnamurthy, Former Election Commissioner,Govt of India at New Delhi , June 30, 2012 [Global Brotherhood Forum] in recognition of Dr Reddys exceptional caliber and outstanding performance in Cancer Research area.
As part of its activities, FFI will be honoring selected galaxy of Indian men and women achievers from all over the world for their outstanding achievements in chosen field of activity. In the past, the publishing house has the privilege of honoring prominent personalities like Matinee idol Dev Anand, Late Sunil Dutt, Cricketer Sachin Tendulkar, and Mohd. Azharuddin, SC Jamir, Chief Minister of Nagaland, Brington Lyngdoh , Chief Minister of Meghalaya, Leading Educationist Shyam Chona, Architects Pheroz Kudianwala, Manik Dastor.
FFI will be bringing out a prestigious book titled The Honored Best Personalities of India. The one page one-person book will cover citation. This proposed book shall be available in the major markets of India, shall be kept in FICCI, ASSOCHAM and offices of other organizations of Industrialists and libraries all over the country.
SUPER ACHIEVERS OF INDIA AWARD and GOLD MEDAL
Dr Shyam Reddy was also awarded the prestigious SUPER ACHIEVERS OF INDIA AWARD with GOLD MEDAL (Certificate of Excellence) (Certificate of Felicitation). Some selected prominent VIPs and others will be presented with this prestigious award to show the world that achievers who have done something special for this country and/ or their countryman and have attained greater excellence in their field of work and enhanced the Indian image.
BHARAT EXCELLENCE AWARD with GOLD MEDAL
Dr Shyam Reddy was awarded the prestigious Bharat Excellence Award with GOLD MEDAL (Certificate of Excellence) (Certificate of Felicitation). These awards are given to selected few most extraordinary men & women from the field of science, technology, education, industry, fine arts, sports, politics, and social work etc., who have done something special for this country and/or their countrymen and have attained greater excellence in the field of their work or who have a touch of genius, or who have scaled the heights against odds to achieve excellence people who have made a mark in their particular activity by any standard world-wide, or those whose work is an inspiration to others. The panelists who select the awardees are some most prominent citizens from India.
SOME PAST RECIPIENTS OF THE AWARD:
Governor Khurasheed Alam Khan; Justice P.N. Bhagwati; M. Fathima Beevi, Member of Parliament; Sunil Dutt; Gopinath Gajapathi; Architect Pheroz Kudianwala, Manik Dastor; Film Stars Dev Anand, Pran, Shammi Kapoor and Rajender Kumar;Sarod Player Ustad Amjad Ali Khan; Cricketers Sunil Gavaskar and Sayed Kirmani.
Dr Shyam Reddy with AWARDS, Gold Medals and Certificates
Center for Prostate Disease ResearchSaturday Distinguished Visiting Professor
Chosen as CPDR Saturday Distinguished Visiting Professor, Center for Prostate Disease Research, Uniformed Services University of Health Sciences, Rockville, MD.
The Center for Prostate Disease Research (CPDR) at the Uniformed Services University of the Health Sciences (USUHS) and the Walter Reed Army Medical Center (WRAMC) hosts lecture series called CPDR Saturday, which has been in existence for over 10 years. CPDR Saturday speakers represent leaders in prostate cancer field.
Link: CPDR Saturday Distinguished Visiting Professor
Left to Right: Dr Robert Dean, Dr David McLeod, Dr E. Shyam P Reddy, Dr Stephen Brassell, Dr Shiv Srivastava
Dr Shyam Reddy received CPDR Recognition Award for Distinguished CPDR Visiting Professor lecture from Dr David McLeod, CPDR Director.
Link: CPDR Saturday Distinguished Visiting Professor, Honors and Awards
Other Links:
BHARAT GAURAV AWARD, India Abroad, Khabar community news maker,
NRI PULSE,Rediff News, The Times of India, Suddi, Indus Business Journal,
Reddy Society, USA Today, Road Runner, TV Masti, India Times, AAPI Journal
LINK: Honors and Awards
Dr Shyam Reddy is chosen as Board member of Carcinogenesis Foundation
Dr Reddy was also appointed as an Editor of Journal of Pharmaceutical Sciences and Pharmacology
Dr Shyam Reddy was also appointed as an Advisory Editorial Board member of the following journals:
1. American Journal of Cancer Science
2. American Journal of Cancer Biology
3. American Journal of Cancer Review
Dr Reddy was also appointed as Editorial board member- J. Hematology & Thromboembolic Diseases.
Title: Molecular Mechanism of Activation of Stem Cell Factor, ERG in Human cancers
ERG and Smad3 Proteins Collaborate to Activate TGF-Beta Mediated Signaling Pathway in ERG-Positive Prostate Cancer Cells (In Press)
In this study, we demonstrate that ERG oncoprotein physically interacts with Smad3 protein and stabilizes phospho-Smad3 protein and thereby enhance TGF-b/Smad3 signaling pathway in prostate cells. Thus, ERG oncoprotein plays an important role in prostate tumorigenesis by using a novel mechanism to activate TGF-beta/Smad3 signaling pathway. These results will have great implications in the diagnosis and treatment of ERG-positive Prostate cancers.
Jinbo Fang, Huali Xu, Chunshu Yang, Sharif Morsalin, Shubhalaxmi Kayarthodi, Kunchala Rungsrisuriyachai, Ujwala Gunnal, Brittany Mckenzie, Veena N. Rao, and E. Shyam P. Reddy, Journal of Pharmaceutical Sciences and Pharmacology, 2014 (In Press).
LINK:
Anti-epilepsy drug Valproic acid targets ERG-positive Prostate cancers
Link: Novel Discovery, Novel Research in Breast cancer, Science CODEX
Call Us
Gene Discovery/Road map to Therapy
Our passion is to find a cure to cancer. Nothing great can be achieved without a passion.
Genes/Gene functions discovered by us:
REFERENCES
1. ERG-1 3476934 PNAS, Oncogene
2. ERG-2 3299708 Science, Oncogene
3. ERG-3 8290279 Oncogene
4. ELK-1 2539641 Science, Nature, Cancer Res
5. ETS-2 1741383
6. ETS-1a 3060801 Oncogene
7. Human Fli-1 1394211 Cancer Res, Oncogene
8. Fli-1b 9764825 Oncogene
9. EWSb 8084618 Oncogene
10. EWS-Fli-1 7503813 Cancer Res, Oncogene
11. EWS-ERG 8084618 Oncogene
12. TLS/FUS-ERG 7970732 Oncogene
13.TLS/FUS 7970732 Oncogene
14. EWS-ATF-1 8552387 Oncogene
15. BRCA2a 10023017 Oncogene, Nature
16. PTENb Unpublished
17. BRCA1a 9538156 Oncology Rep.
18. BRCA1b 9538156 Oncology Rep.
19. Delta ELK-1 8417810 Cancer Res.
20. H2-K K Gene 3840763 Gene
20. mi-PEP-200a In PRESS
21. mi-PEP-200b In PRESS
22. Seminalplasmin 377100 377101 Nature
(Nature Back to back papers) Ph.D. Thesis
Please see achievements section for details (top of the page)
OUR COLLEAGUES INVOLVED IN INNOVATION RESEARCH and NOVEL DISCOVERIES
Genes/Gene functions discovered by us:
REFERENCES
1. ERG-1 3476934 PNAS, Oncogene
2. ERG-2 3299708 Science, Oncogene
3. ERG-3 8290279 Oncogene
4. ELK-1 2539641 Science, Nature, Cancer Res
5. ETS-2 1741383
6. ETS-1a 3060801 Oncogene
7. Human Fli-1 1394211 Cancer Res, Oncogene
8. Fli-1b 9764825 Oncogene
9. EWSb 8084618 Oncogene
10. EWS-Fli-1 7503813 Cancer Res, Oncogene
11. EWS-ERG 8084618 Oncogene
12. TLS/FUS-ERG 7970732 Oncogene
13.TLS/FUS 7970732 Oncogene
14. EWS-ATF-1 8552387 Oncogene
15. BRCA2a 10023017 Oncogene, Nature
16. PTENb Unpublished
17. BRCA1a 9538156 Oncology Rep.
18. BRCA1b 9538156 Oncology Rep.
19. Delta ELK-1 8417810 Cancer Res.
20. mi-PEP-200a In PRESS
21. mi-PEP-200b In PRESS
22. H2-K K Gene 3840763 Gene
23. Seminalplasmin 377100
377101 (Nature Back to back papers) Ph.D. Thesis
Functionotherapeutics, Cancer Biology Program, Morehouse School of Medicine Receives 2020 Best of Atlanta Award
Atlanta Award Program Honors the Achievement
ATLANTA January 9, 2020 -- Functionotherapeutics, Cancer Biology Program, Morehouse School of Medicine has been selected for the 2020 Best of Atlanta Award in the Colleges & Universities category by the Atlanta Award Program.
Each year, the Atlanta Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Atlanta area a great place to live, work and play.
Various sources of information were gathered and analyzed to choose the winners in each category. The 2020 Atlanta Award Program focuses on quality, not quantity. Winners are determined based on the information gathered both internally by the Atlanta Award Program and data provided by third parties.
About Atlanta Award Program
The Atlanta Award Program is an annual awards program honoring the achievements and accomplishments of local businesses throughout the Atlanta area. Recognition is given to those companies that have shown the ability to use their best practices and implemented programs to generate competitive advantages and long-term value.
The Atlanta Award Program was established to recognize the best of local businesses in our community. Our organization works exclusively with local business owners, trade groups, professional associations and other business advertising and marketing groups. Our mission is to recognize the small business community's contributions to the U.S. economy.
SOURCE: Atlanta Award Program
Our passion is to find a cure to cancer. Nothing great can be achieved without a passion
"The postings on this site are my own and don't necessarily represent my
organization's positions, strategies or opinions."
Copyright this business. All rights reserved.
Dr E. Shyam P. Reddy,
Functionotherapeutics,
Professor and Director, Cancer Biology Program, Dept of OB/GYN, Morehouse School of Medicine, 720 Westview Drive
Atlanta, GA 30310
ph: 404-756-5230
fax: 678-623-5999
ereddy