Functionotherapeutics: Gene Discovery and Function based Therapeutic Strategies

Thus, these results (proving the existence of pri-miRNA encoded biologically active peptides/proteins in mammalian cells) will revolutionize the biology field per se as they may be involved in growth and development of all humans, animals, plants and other living creatures. Based on our results, we predict that there will be a great number of publications describing novel pri-miRNA encoded peptides/small proteins in mammalian cells will be forthcoming in future that may change the landscape of Biology per se. NIH/NSF/DOD may have to dedicate Billions of Dollars budget for the analysis and study of these novel proteins/peptides.

Dr Reddy and his colleagues at Morehouse School of Medicine has decoded Non-coding DNA (JUNK DNA, 98% of Human Genome) and its non-coding RNA and discovered novel category Pri-Micro RNA-Encoded Proteins/ Peptides in mammalian cells (Importance of these novel miPEPs were reviewed in three reviews shown below). We have shown that Pri-Micro RNA-200a and Pri-Micro RNA-200b encode NOVEL Tumor Suppressors (mi-PEP-200a and mi-PEP-200b) which inhibit migration of Prostate and Breast cancer cells. Recently, we have raised antibodies to miPEP-200s and shown their presence in normal breast and prostate cancer cells (manuscript, in press). One can use these mi-PEPs as biomarkers and precision therapeutic agents to all Human diseases including all Cancers, Alzheimer’s, Parkinson, Cardiovascular diseases (In press) and Pulmonary diseases etc.and also their treatment .

This finding suggests that thousands of new/novel functional proteins/peptides are encoded by pri-miRNAs in the mammalian cells. This will revolutionize the future biology, diagnosis and precision therapy.